Micro‐Nanocarriers Based Drug Delivery Technology for Blood‐Brain Barrier Crossing and Brain Tumor Targeting Therapy (Small 45/2022)
نویسندگان
چکیده
Blood–Brain Barrier Therapy The blood–brain barrier (BBB) is a bottleneck in the treatment of brain tumors. In article number 2203678, Liang Wang, Yinyan Lin Feng, and co-workers summarize current approaches to overcome BBB, such as use “Trojan horse” molecular modifications for deception, describe variety micro-nanocarriers targeted tumor therapy.
منابع مشابه
Targeting blood-brain-barrier transcytosis – perspectives for drug delivery
Efficient transcytosis across the blood-brain-barrier (BBB) is an important strategy for accessing drug targets within the central nervous system (CNS). Despite extensive research the number of studies reporting successful delivery of macromolecules or macromolecular complexes to the CNS has remained very low. In order to expand current research it is important to know which receptors are selec...
متن کاملRecent Developments in Targeted Drug Delivery System for Crossing Blood- Brain Barrier: a Review
Targeted drug delivery systems have been used to deliver drugs in the disease sites of the body. This may reduce potential side effects of drugs and improve their therapeutic effects. Development of brain targeting drug delivery system help in the treatment of disorders related to brain. The most challenging research topic in pharmaceutical sciences is brain targeting drug delivery system. Most...
متن کاملImpacts of blood-brain barrier in drug delivery and targeting of brain tumors.
INTRODUCTION Entry of blood circulating agents into the brain is highly selectively con-trolled by specific transport machineries at the blood brain barrier (BBB), whose excellent barrier restrictiveness make brain drug delivery and targeting very challenging. METHODS Essential information on BBB cellular microenvironment were reviewed and discussed towards impacts of BBB on brain drug delive...
متن کاملDrug Therapy for Small Abdominal Aortic Aneurysm
Dear Editor,Abdominal aortic aneurysm is often asymptomatic, less recognized, and causes considerable mortality and morbidity, if missed. The incidence varies from country to country and the occurrence is influenced by modifiable (smoking, coronary heart disease, hypertension, dyslipidemia, and prolonged steroid therapy) and non-modifiable risk factors (increasing age, male gender, and positive...
متن کاملBrain Mini-Workshop: Blood Brain Barrier and Targeted Drug Delivery
Drugs are currently being developed for the treatment of serious brain disorders including glioblastoma, Parkinson’s disease, and Alzheimer’s disease. These include chemotherapeutic drugs and those based on neurotrophic factors such as glial cell-derived neurotrophic factor (GDNF), brain-derived neurotrophic factor (BDNF), and neurturin (NTN). Neurotrophic factors have therapeutic potential for...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Small
سال: 2022
ISSN: ['1613-6829', '1613-6810']
DOI: https://doi.org/10.1002/smll.202270241